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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development

ResearchThere is an opportunity for further research aimed at developing more innovative GABA-targeting therapies.

Beyond Pharmacological Therapy for the Treatment of Epilepsy: Creating Electrodes to Prevent Seizures by Stimulating the Brain

DiscoveryConsidering the limitations of pharmacological therapy for many epilepsy patients, it is essential to increase the range of available treatments, and the work from Dr. Litt’s laboratory makes a cure for epilepsy closer to becoming a reality.

Outcomes in the Treatment of Psychogenic Nonepileptic Seizures (PNES) with Cognitive Behavioral Therapy-Informed Psychotherapy

ResearchPatients treated with cognitive behavioral therapy-informed psychotherapy with a minimum of 7 sessions in 3 months did not have significant improvement.

Study Finds Diet Therapy to be Most Effective Therapy in Children with Myoclonic-Atonic Seizures (Doose Syndrome)

ResearchEpilepsy with myoclonic-atonic seizures (EMAS) is a rare childhood onset epileptic encephalopathy. There is no clear consensus for recommended treatments, and pharmacoresistance is common...Read More

Treatment Comparison of Perampanel (Fycompa®) Versus Brivaracetam (Briviact®) as Add-On Therapy for Epilepsy

ResearchPerampanel and brivaracetam are effective for the add-on treatment of focal-onset seizures and display similar adverse event profiles.

Medical Treatment in Infants and Young Children with Epilepsy: Off-Label Use of Antiseizure Medications Survey Report of ILAE Task Force Medical Therapies in Children

ResearchOur results reveal that several ASMs (e.g. topiramate, oxcarbazepine, benzodiazepines) are prescribed “off-label” in distinct scenarios of young children with epilepsy. In addition, recent scientific guidelines were not always adopted by several survey respondents, suggesting a potential knowledge gap.
Pre-Clinical Testing of an Optimised Gene Therapy for the Treatment of Epilepsy

Pre-Clinical Testing of an Optimised Gene Therapy for the Treatment of Epilepsy

Grants AwardedIn this study, the team will optimize a gene therapy for potential human clinical studies.
LivaNova VNS Therapy System for Drug-Resistant Epilepsy Could Save $77K Per Patient Over Five Years

LivaNova VNS Therapy System for Drug-Resistant Epilepsy Could Save $77K Per Patient Over Five Years

ResearchLivaNova says a new cost analysis found that Vagus Nerve Stimulation Therapy (VNS Therapy) System results in lower resource utilization and lower cost for drug-resistant epilepsy patients when compared to continued treatment with anti-epileptic drugs.

Sense of Control, Selective Attention, Cognitive Inhibition, and Psychosocial Outcomes after Retraining and Control Therapy (ReACT) in Pediatric Functional Seizures

ResearchDifferences in sense of control, cognitive inhibition, and selective attention in pediatric functional seizures (FS) versus matched controls implicate these as potential novel treatment targets. Retraining and Control Therapy (ReACT), which targets these factors, has been shown in a randomized controlled trial to be effective in improving pediatric FS with 82% of patients having complete symptom remission at 60 days following treatment.

Efficacy and Safety of Ketogenic Dietary Therapies in Infancy. A Single-Center Experience in 42 Infants Less Than Two Years of Age

ResearchKetogenic dietary therapies are useful and effective treatments in infancy. Side effects are frequent but mild and easy to manage.
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