According to the study, “Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy” [1]:
[Researchers] propose that growth hormone releasing hormone (GHRH) may exert an antiepileptic effect.
The primary finding of this study is that growth hormone releasing hormone expression was significantly increased in the brains of both patients with temporal lobe epilepsy and in two mouse models of epilepsy induced by either kainic acid or pentylenetetrazol.
In addition, growth hormone releasing hormone co-localized with presynaptic and postsynaptic inhibitory neurons. Interestingly, [researchers] confirmed that growth hormone releasing hormone and activate ?-aminobutyric acid (GABA) receptors (GABAARs) interacted.
Therefore, [researchers] propose that growth hormone releasing hormone participates in anti-epileptic processes by increasing ?-aminobutyric acid levels and activating ?-aminobutyric acid receptors.