Article published by Global Newswire
Neurona Therapeutics recently published data on the development and characterization of human stem cell-derived, medial ganglionic eminence inhibitory interneurons for the potential treatment of focal epilepsy. In a preclinical study, administration of a single dose of the cells in a chronic model of drug-resistant mesial temporal lobe epilepsy (MTLE) resulted in long-lasting and consistent suppression of focal seizures, as well as improvements in neuropathology and an increase in survival. The study also demonstrated a potentially broad, safe, and effective dosing range in the model. The data support the development of Neurona Therapeutics’ regenerative cell therapy candidate, NRTX-1001, which is being evaluated in an ongoing Phase I/II clinical trial of a one-time dose in people with drug-resistant MTLE (NCT05135091).