April 28, 2017

Positive airway pressure therapy improved seizure control in epileptic patients with obstructive sleep apnea

Sleep study, “1145 Long-Term Seizure Control in Epileptic Patients with Obstructive Sleep Apnea Using Positive Airway Pressure Therapy” found [1]:

[There were] better 1-year seizure outcomes in people with epilepsy and Positive Airway Pressure-treated Obstructive Sleep Apnea compared with Untreated Obstructive Sleep Apnea and No Obstructive Sleep Apnea.

[Researchers] investigated the effect of positive airway pressure therapy on long-term seizure outcomes in adults with epilepsy who underwent polysomnography at Cleveland Clinic (1997–2016). Seizure outcomes included mean % seizure reduction, ?50% seizure reduction from baseline (%, responder rate), and ? 50% seizure reduction or seizure free at both baseline and follow up (%, successful outcome).

Successful outcome was achieved more often in Positive Airway Pressure-treated (84%) than Untreated Obstructive Sleep Apnea (57%; p=0.002) or No Obstructive Sleep Apnea (66%; p=0.009) groups. [The results] expand existing literature supporting the impact of sleep therapies on seizure control in people with epilepsy.