Back to top
March 6, 2018
Study: Extrahippocampal high-frequency oscillations during epileptogenesis
Research

An Epilepsia study demonstrates an association between an increased rate of widespread high-frequency oscillations and the later development of epilepsy, suggesting the formation of large-scale distributed pathological networks during epileptogenesis.

Summary: The current study aimed to investigate the spatial and temporal patterns of high-frequency oscillations (HFOs) in the intra-/extrahippocampal areas during epileptogenesis. Local field potentials were bilaterally recorded from hippocampus (CA1), thalamus, motor cortex, and prefrontal cortex in 13 rats before and after intrahippocampal kainic acid (KA) lesions. HFOs in the ripple (100-200 Hz) and fast ripple (250-500 Hz) ranges were detected and their rates were computed during different time periods (1-5 weeks) after KA-induced status epilepticus (SE).

Recurrent spontaneous seizures were observed in 7 rats after SE, and the other 6 rats did not develop epilepsy. During the latent period, the rate of hippocampal HFOs increased at the ipsilateral site of the KA lesion in both groups, and the HFO rate was significantly higher in the animals that later developed epilepsy. Animals that later developed epilepsy also demonstrated widespread appearance of HFOs, in both the ripple and the fast ripple range, whereas animals that did not develop epilepsy only exhibited changes in the ipsilateral intrahippocampal HFO rate. 

Learn More

 

Related News

September 17, 2018
Characterizing Pig Hippocampus Could Improve Translational...

Researchers are developing a superior animal model of neurological conditions. The results establish the pig as a promising preclinical research...

Read More
September 11, 2018
High Electroencephalographic Seizure Exposure is Associated...

Adequate identification and management of electroencephalographic seizures with judicious use of anti-seizure medications may optimize outcomes...

Read More
September 4, 2018
Brain-Protein Study Could Lead To New Epilepsy Drugs

The research suggests the protein collybindin could play a role in the brain activity that activates or inhibits seizures.

Read More