The study investigates the association between normalization of serum sodium levels and bone markers in patients with epilepsy and chronic hyponatremia.
The study is a randomized, single blinded, placebo controlled study where participants will be randomized to either treatment with salt tablets or placebo tablets through 4 months. At the beginning and end of the 4 months bone markers will be measured.
The investigators null-hypothesis is that there will be no difference in bone markers before or after the intervention.
Ages Eligible for Study: 18 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
- Epilepsy requiring treatment for at least 2 years
- Known hyponatremia (2 subsequent s-sodium values < 136 mmol/l)
- Age 18-80 years
- Danish speaking
- Signed form of prior consent
- Pregnancy and breastfeeding
- Known osteoporosis. DXA scan < -2.5 T-score. Z-score is used for patients 50 years or younger.
- Undergoing treatment for osteoporosis
- Undergoing treatment with salt tablets
- Known SIADH
- Severe concomitant disease such as cancer or ischemic heart disease
- Alcohol, drug or substance abuse