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Infantile Spasms Initiative

The initiative's main goal is to support collaborative, milestone‐driven efforts that advance the understanding of the underlying pathology of infantile spasms and lead to the development of a disease‐modifying therapy or cure for infantile spasms.

About the Initiative

In a groundbreaking, multidisciplinary 'team science' initiative, CURE awarded grants to eight teams of investigators to advance cutting-edge research to find a cure for infantile spasms, a rare childhood epilepsy syndrome. Infantile Spasms (IS) can have profoundly negative long-term developmental and cognitive consequences, and the treatments that are currently available are often ineffective and frequently associated with substantial adverse effects.

The lead investigators in CURE’s IS Initiative, a scientific "dream team," bring a wealth of expertise and perspectives that span adult and pediatric neurology, basic mechanisms of the epilepsies, animal modeling, human genetics and clinical trial design and execution.


"A big part of what we do at CURE is break down barriers—specifically barriers that have impeded progress toward a cure." - Susan Axelrod


The projects associated with this multi-year, multi-million dollar initiative involve investigators at multiple institutions emphasizing a novel, team approach to research. This unconventional research method encourages the investigators to function as a united team and remain focused on the common goal of identifying underlying causes and finding a cure.

“The Infantile Spasms Initiative is unique in that it involves focused multidisciplinary ‘team science’ that will be driven by the outcomes of the research in a responsive and timely manner. We are extremely excited about the potential that this focused effort has to further our understanding of the causes of infantile spasms and the translation of basic science into better treatments and eventually a cure for IS."

– Dr. H. Steve White, Senior Research Advisor, CURE



Meet the Multidisciplinary Research Team

  • Chris Dulla, PhD – Tufts University
  • Aristea Galanopoulou, MD, PhD – Albert Einstein College of Medicine
  • Jeff Noebels, MD, PhD – Baylor College of Medicine
  • John Swann, PhD – Baylor College of Medicine
  • Libor Velisek, MD, PhD – New York Medical College
  • Manisha Patel, PhD – University of Colorado Denver
  • Doug Nordli, MD – Children’s Hospital of Los Angeles
  • Elliott Sherr, MD, PhD – University of California, San Francisco


Related Research

Acquired Interneuronopathy in a Mouse Model of Infantile Spasms
Sacha D. Nelson, MD, PhD
Brandeis University
Identification of Aberrant Gene Regulatory Networks in Infantile Spasms
Senthil Sundaram, MD
Wayne State University
Preventing Autism and Other Long-term Complications of Infantile Spasms (IS)
Lionel Carmant, MD
 CHU-Sainte-Justine, Montreal, Canada

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