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Effectiveness and Tolerability of Perampanel in Adolescents and Adults as a First Add-On Therapy: An Observational, Multicenter Study
ResearchThis study finds that Perampanel at low doses and as a first add-on treatment is a good option for patients with focal and generalized epilepsy.Researchers Clarify How Ketogenic Diets Treat Epilepsy, Guiding Future Therapy Development
ResearchComprehensive review gives researchers, clinicians and families a clearer understanding of why the diet works and where new treatments could emerge.Novel Gene Therapy Shows Promise in Targeting a Mutation Linked to Epilepsy
ResearchA new study from the Epi25 Collaborative, a group of over 200 researchers around the world working to uncover the genetic basis of epilepsy, has revealed new potential targets for treatment, both shared by and unique to different subtypes of epilepsy.Gene Therapy Offers Hope for Severe Epilepsy
ResearchA study published this month in Science Advances by a team of researchers at Macquarie University’s Dementia Research Centre showed their treatment could prevent seizures in mice by clearing build ups of a protein in the brain.
Advancing Toward Gene Therapies for Rare Epilepsies
DiscoveryA humble side project has developed into a potential curative treatment on the cusp of human clinical trials, thanks to CURE Epilepsy funding.The Discovery of a New Step in How Brain Cells Work Could Lead to New Therapies for Epilepsy
ResearchResearchers have identified a critical new step in how brain cells function in people with one of the most common forms of epilepsy. This could lead to new treatment approaches for people with drug-resistant epilepsy.Sex Differences in the Epilepsies and Associated Co-Existing Illnesses: Implications for Use and Development of Drug Therapies
ResearchIn this review, the authors discuss the current knowledge on sex differences in epilepsy and associated co-existing disorders, with emphasis on those aspects most informative for the development of new drug treatments.
Gene Therapy for Seizures in a Mouse Model of a Pathogenic GRIK2 Variant
Grants AwardedDr. Swanson’s team will test whether reducing the activity of the overactive kainate receptor, using a gene therapy approach, can improve seizures and other behaviors in a new mouse model that carries the same genetic change found in people.
A Cure at Last: Advancing RNA Therapy from Bench to Bedside
Grants AwardedThis team is working on developing NMT.001, a new antisense oligneucleotide therapy for the treatment of drug-resistant epilepsy.