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Gene Therapy for the Catastrophic Type 1 Progressive Myoclonus Epilepsy (EPM1)
Grants AwardedResults from this project will lead to initial data on a possible treatment for a devastating form of epilepsy.
Target Optimization in Precision Treatment of KCNT1-Related Epilepsy
Grants AwardedDr. Tobin will test strategies to optimize cutting-edge gene and drug therapies by selectively targeting the most severely affected cells and brain networks in a mouse model of KCNT1-related epilepsy.
Intranasal Delivery Of Sustained-Release Anticonvulsant Neuropeptide Nanoparticles In Seizure Therapy
Grants AwardedThe goal of this Dr. Kubek’s research is to develop a neuropeptide-containing nanoparticle nasal spray for seizure therapy.
Treatment Of Epilepsy With A Catalytic Antioxidant
Grants AwardedThe goal of this project is to conduct a proof-of-principle study to determine if early treatment with a novel catalytic antioxidant prevents metabolic dysfunction and epilepsy in mice lacking a critical mitochondrial antioxidant.
Identification Of Novel Therapies For Intractable Pediatric Epilepsy Due To The Cortical Dysplasias
Grants AwardedOur ability to test potential therapies directly on tissue from an affected child as well as on neurons expressing the same genetic mutation as that child will pave the way for the application of “personalized medicine” techniques to the treatment of intractable pediatric epilepsy.
Silencing Hyperactive Neurons as a Treatment for Temporal Lobe Epilepsy
Grants AwardedThe goal of Drs. Perez-Reyes and Kapur’s research is to develop a novel gene therapy tool that will silence hyperactive neurons that cause seizures by selective expression of a potassium leak channel.
New Treatments For Epilepsy That Regulate Complement Activity
Grants AwardedWe propose to test the hypothesis that virus infection activates the complement system in the brain that in turn increases inflammation which ultimately contributes to the development of seizures.
Understanding Epilepsy
Understanding Epilepsy - providing people with epilepsy, their caregivers, and loved ones with the information they need in an accessible way
