Back to top
March 9, 2018
Study: Benign Rolandic Epilepsy and Generalized Paroxysms: An examination of 13 patients

Conclusions: [Researchers] found evidence that patients with benign rolandic epilepsy (BRE) may have generalized EEG discharges at onset as the sole manifestation lasting throughout the course of the syndrome. In some, focal paroxysms developed later. The course was benign. In our group of patients, clinical features and evolution were similar to those of typical cases of BRE. Response to valproic acid and levetiracetam was found to be particularly good.

Purpose: To present a retrospective study of 13 children with benign epilepsy with centrotemporal spikes (BECTS), also known as benign rolandic epilepsy (BRE), associated with generalized spikes and waves as the only EEG manifestation at onset.

Method: Charts of children with typical clinical criteria of BRE electroclinically followed-up between February 2000 and February 2015 were reviewed.

Results: Among 309 patients who met the electroclinical criteria of BRE, we identified 13 children who presented with the typical clinical manifestations but who, on the EEG, only had generalized paroxysms at onset that continued along the course of the syndrome. Generalized spike-and-wave discharges were observed in all patients when awake and during sleep (100%). During the evolution no particular electroclinical pattern was observed. The patients responded well to antiepileptic drugs, such as valproic acid and levetiracetam. Outcome was good in all patients.

Learn More


Related News

September 17, 2018
Characterizing Pig Hippocampus Could Improve Translational...

Researchers are developing a superior animal model of neurological conditions. The results establish the pig as a promising preclinical research...

Read More
September 11, 2018
High Electroencephalographic Seizure Exposure is Associated...

Adequate identification and management of electroencephalographic seizures with judicious use of anti-seizure medications may optimize outcomes...

Read More
September 4, 2018
Brain-Protein Study Could Lead To New Epilepsy Drugs

The research suggests the protein collybindin could play a role in the brain activity that activates or inhibits seizures.

Read More