CURE Award, Funded by the Christopher Donalty Interdisciplinary Award

A Hybrid Cellular-Silicon Neural Prosthetic for Epilepsy

Jenna L. Rickus, PhD, - Pedro L. Irazoqui, PhD
Purdue University, West Lafayette, IN

The major treatment problems facing patients with epilepsy are resistance to drugs and unwanted side effects. Targeting treatment to a specific area of the brain immediately prior to and during a seizure would present a significant advancement. The goal of this project, which melds biology and engineering, is to develop a novel, cell-based neural prosthetic to electrically detect a seizure before it occurs and respond by stimulating transplanted cells to rapidly release GABA (a critical therapeutic target in epilepsy), thereby preventing the seizure.


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