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May 24, 2019

What’s the Right Amount of ‘Zapping’ in Epilepsy Laser Surgery?

In the largest study of its kind to date, researchers across 11 centers analyzed data on a relatively new minimally invasive alternative surgery for epilepsy, and discovered changes that could make the procedure more effective in both laser ablation and standard surgery.

May 24, 2019

Study Explores Way to Automate Detection of Sudden Unexpected Death in Epilepsy Risk Factors in Electronic Medical Records

This study evaluated the feasibility and generalizability of using regular expressions to identify SUDEP risk factors in electronic medical records and barriers to generalizability.

May 23, 2019

Improving Road Safety by Using a New Model to Determine Fitness to Drive in Epilepsy

The purpose of this study was to determine the feasibility of using a decision tree to determine if individuals with epilepsy are fit to drive, according to the Australian standards.

May 23, 2019

Review: New Anti-Seizure Medication for Elderly Patients with Epilepsy

This review finds that to date, few clinical investigations consider the elderly population specifically despite the increased risk factors.

May 23, 2019

A New Frontier for Epilepsy Brain Imaging

Advanced neuroimaging with artificial-intelligence prediction hopes to transform management of epilepsy, reducing clinical uncertainty and leading to earlier decisions and better selection of effective treatments.

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May 21, 2019

CURE Discovery: New Genetic Models of Epileptic Encephalopathies Deepen Our Understanding

Inhibitory brain signaling was diminished in mice modeling epileptic encephalopathy, causing excessive neuronal excitation, seizures, and other neurological features seen in humans with EE.

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May 20, 2019

UCB announces NAYZILAM® (midazolam) nasal spray now approved by FDA to treat intermittent, stereotypic episodes of frequent seizure activity in people living with epilepsy

The FDA has approved the first nasal spray rescue medication to treat seizure clusters in people over 12 years of age and older with epilepsy.

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May 16, 2019

New Drug Could Help Treat Neonatal Seizures

A new drug that inhibits neonatal seizures in rodent models could open up new avenues for the treatment of epilepsy in human newborns.

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May 16, 2019

Brain Network Activity Can Improve in Epilepsy Patients After Surgery

Successful temporal lobe epilepsy surgery can improve brain connectivity similar to patterns seen in people without epilepsy, according to a new study.

May 16, 2019

Widespread Off-Label Use of Epilepsy Medications Could Put Some Patients at Risk

Gabapentinoids, initially intended to treat epilepsy, are now commonly prescribed as a pain killer to the general population, including to elderly patients with multiple conditions.

May 15, 2019

Clinical Study Finds Two Types of SCN8A-Related Epilepsy: Slowly Emerging or Sudden Onset of Epilepsy

Objective: To describe the mode of onset of SCN8A-related severe epilepsy in order to facilitate early recognition, and eventually early treatment with sodium channel blockers. Methods: Researchers reviewed the phenotype of patients carrying a mutation in the SCN8A gene, among a multicentric cohort of 638 patients prospectively followed by several pediatric neurologists. The study focused on the way clinicians made the diagnosis of epileptic encephalopathy, the very first symptoms, electroencephalography (EEG) findings, and seizure types. The team made genotypic/phenotypic correlation based on epilepsy-associated missense variant localization over the protein. Results: The study found 19 patients carrying a de novo mutation of SCN8A, representing 3% of our cohort, with 9 mutations being novel. Age at onset of epilepsy was 1 day to 16 months. The team also found two modes of onset: 12 patients had slowly emerging onset with rare and/or subtle seizures and normal interictal EEG (group 1). The first event was either acute generalized tonic-clonic seizure (GTCS; Group  1a, n = 6) or episodes of myoclonic jerks that were often mistaken for sleep-related movements or other movement disorders (Group 1b, n = 6). Seven patients had a sudden onset of frequent tonic seizures or epileptic spasms with abnormal interictal EEG leading to rapid diagnosis of epileptic encephalopathy. Sodium channel blockers were effective or nonaggravating in most cases. Significance: SCN8A is the third most prevalent early onset epileptic encephalopathy gene and is associated with two modes of onset of epilepsy.

May 14, 2019

Brivaracetam Not Associated with an Increase in Anger Levels in People with Focal or Generalized: A Prospective Open-Labelled Controlled Study

Brivaracetam is not associated with an increased level of anger in patients with either focal or generalized epilepsy, however an improvement in anger levels is possibly influenced by a good seizure response.

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