To answer the question posed in the title of the manuscript, the authors critically examined the connection between ketogenic diet (KD), gut microbiota (GM), and epilepsy.
The study of high frequency oscillations (HFO) [a type of brain activity] in the electroencephalogram (EEG) as biomarkers of epileptic activity has merely focused on their spatial location and relationship to the epileptogenic zone.
Approximately one-third of people living with epilepsy are unable to obtain seizure control with the currently marketed antiseizure medications (ASMs), creating a need for novel therapeutics with new mechanisms of action.
Pharmacoresistance and the lack of disease?modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy. The aim of the present study was to compare the molecular landscape of the intra?amygdala kainic acid model of status epilepticus in mice with findings in resected brain tissue from patients with drug?resistant temporal lobe epilepsy (TLE).
The COVID-19 pandemic and related lockdown measures drastically changed health care and emergency services utilization. This study evaluated trends in emergency department (ED) access for seizure-related reasons in the first 8 weeks of lockdown in Italy.
Advances in gene discovery have identified genetic variants in the solute carrier family 6 member 1 (SLC6A1) gene as a monogenic cause of neurodevelopmental disorders, including epilepsy with myoclonic atonic seizures, autism spectrum disorder, and intellectual disability.