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December 11, 2018

CURE Update: Scholarships, Infantile Spasms Resources, and Giving Opportunities

Discover the latest about what's happening at CURE and in our community in the December 2018 CURE Update from Chief Scientific Officer, Laura Lubbers!

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December 11, 2018

CURE Discovery: New Ultraflexible Electrodes for Minimally Invasive Electrical Recordings

A less invasive yet more accurate, safe, and effective method of recording seizures from deep layers of the brain may now be possible, thanks to the work of CURE grantee Dr. Flavia Vitale.

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December 10, 2018

The Refractory Epilepsy Screening Tool for Lennox–Gastaut Syndrome (REST-LGS)

Study finds the Refractory Epilepsy Screening Tool for LGS may be a valuable clinical tool in identifying patients requiring further diagnostic evaluation for LGS.

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December 10, 2018

Genome-Wide Mega-Analysis Identifies 16 Loci and Highlights Diverse Biological Mechanisms in the Common Epilepsies

Results from a genome-wide mega-analysis show an enrichment for monogenic epilepsy genes as well as known targets of antiepileptic drugs. Using SNP-based heritability analyses, researchers disentangle both the unique and overlapping genetic basis to seven different epilepsy subtypes.

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December 10, 2018

Tolerability of Antiepileptic Drugs in Patients with Newly Diagnosed Epilepsy: A 30-Year Longitudinal Cohort Study

A history of intolerable adverse drug reactions has a large impact on the tolerability of future antiepilepsy drug regimens.

December 10, 2018

HudsonAlpha Scientists Identify “Poisonous” Piece of Genetic Code Causing Infant Seizures

Research finds when a "poison" exon on the SCN1A gene is incorporated, it prematurely cancels the production of a crucial protein, which disrupts neural function leading to seizure disorders.

December 7, 2018

Childhood Seizures and Risk of Psychiatric Disorders in Adolescence and Early Adulthood: a Danish Nationwide Cohort Study

Children with epilepsy and febrile seizures—with and without concomitant epilepsy—are at increased risk of developing a broad range of psychiatric disorders in later life.

December 6, 2018

Teens and Adults with Epilepsy at Increased Risk for Depression, Studies Show

Teens and adults with epilepsy are at higher risk for depression than the general population and should be screened regularly and provided therapy if needed.

December 6, 2018

Effectiveness and Tolerability of Perampanel in Adolescents and Adults as a First Add-On Therapy: An Observational, Multicenter Study

This study finds that Perampanel at low doses and as a first add-on treatment is a good option for patients with focal and generalized epilepsy.

December 6, 2018

Improved Everyday Executive Function with Fenfluramine HCL Oral Solution (FINTEPLA®): Results from a Phase 3 Study in Children and Young Adults with Dravet Syndrome

Patients taking certain dosages of fenfluramine showed significant and clinically meaningful improvements in behavior regulation, emotion regulation, and planning and organization.

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December 6, 2018

Efficacy, Safety, and Tolerability of Eslicarbazepine Acetate in Post-Stroke Epilepsy: Real-World Evidence from the Euro-Esli Study

Eslicarbazepine acetate ESL was effective and well tolerated in a small subgroup of patients with post-stroke epilepsy, researchers state,

December 5, 2018

Long-Term Safety Experience of NAYZILAM™ in Subjects with Seizure Clusters

The open-label ARTEMIS-2 study supports the long-term safety of repeated usage of midazolam nasal spray in the outpatient setting to treat seizure clusters.

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