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March 18, 2019

Study Finds Antiepileptic Drug Withdrawal Increases the Likelihood for Epileptic Seizures but Does Not Prolong Seizure Duration

Although anti-epileptic drug withdrawal increases the likelihood for epileptic seizures, it did not prolong the seizure duration, nor did it increase the rate of secondary generalization in this study.

March 18, 2019

AQB-565 Shows Promise in Preclinical Testing in the Model of Epileptic Spasms During Infancy: Head-to-Head Comparison with ACTH

Researchers tested efficacy of a novel fusion peptide AQB-565 in a model of infantile spasms consisting of prenatal exposure to betamethasone and repeated postnatal trigger of spasms with N-methyl-d-aspartic acid (NMDA).

March 13, 2019

ADHD Meds Safe With Epilepsy, Study Finds

Research provides reassurance that taking ADHD medications won't raise risk of seizures in people with epilepsy.

March 13, 2019

Detecting Subtle Epileptogenic Lesions in MRI-Negative Pediatric Epilepsy

Children with drug-resistant focal epilepsy and focal cortical dysplasia who undergo complete resection of Morphometric Analysis Program (MAP)-positive regions are more likely to experience seizure-free outcomes compared with children who receive no or partial resection.

March 12, 2019

Biomarkers of Cardiac Stress After Generalized Convulsive Seizures Identified

Biomarkers such as high?sensitive troponin T (hsTNT), copeptin, and soluble urokinase plasminogen activator receptor (suPAR) may be helpful to identify cardiac stress after generalized convulsive seizures (GCS) in patients with refractory epilepsy.

March 12, 2019

The Spectrum of Neuroimaging Findings in Febrile Infection-Related Epilepsy Syndrome (FIRES): A Literature Review

A comprehensive review of the MRI characteristics in all reported patients with a FIRES diagnosis, describing the findings in the acute and chronic phases of the disease, and discussing possible pathogenesis and radiologic differential diagnoses.

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March 12, 2019

White Matter, Cortical Volume May Predict Risk for Late-Onset Epilepsy

White matter hyperintensities and lower cortical volume scores are associated with a higher risk for late-onset epilepsy in older adults.

March 11, 2019

Review: Management of Epilepsy in Women

Hormonal changes occurring throughout a woman's life can influence and be influenced by seizure mechanisms and antiepileptic drugs, presenting unique management challenges.

March 11, 2019

Robotics Makes Intractable Epilepsy Surgery More Accurate

Patients who had a minimally invasive evaluation procedure experienced fewer complications, and those who went on to have brain surgery were more likely to be seizure-free than patients who had the more invasive evaluation procedure.

March 11, 2019

A Screening Questionnaire for Generalized Tonic-Clonic Seizures: Hospital-Based Validation Versus Field-Validation Method

This screening questionnaire showed a significantly lower level of sensitivity when validated in the field, confirming that hospital?based validation can lead to an overestimation of sensitivity.

March 11, 2019

Insights on Rare MICPCH Syndrome Could Help with Autism, Epilepsy

This study found an increase in the excitatory synaptic function and decrease in the inhibitory synaptic function only in CASK mutant neurons, but not in wild-type neurons in the same brain.

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March 8, 2019

Less-Invasive Procedure Helps Surgeons Pinpoint Epilepsy Surgical Candidates

A minimally invasive procedure to determine whether patients with drug-resistant epilepsy are candidates for brain surgery is safer, more efficient, and leads to better outcomes than the traditional method.

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