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May 10, 2022

CURE Epilepsy Update: May 2022

Check out the May Update for information on our newly announced Catalyst grantees, mental health resources, an epilepsy awareness campaign, new episodes of Seizing Life, and more exciting updates.

May 6, 2022

ILAE Classification and Definition of Epilepsy Syndromes with Onset in Neonates and Infants: Position Statement by the ILAE Task Force on Nosology and Definitions

The International League Against Epilepsy (ILAE) Task Force on Nosology and Definitions proposes a classification and definition of epilepsy syndromes in the neonate and infant with seizure onset up to 2 years of age.

May 4, 2022

Leveraging Electronic Patient Diaries in SUDEP Risk Evaluation

We demonstrated that the population using the SeizureTracker™ tool can be a valuable population for expanding investigation of SUDEP risk factors and is a first step towards establishing a large sample with a method to ascertain data prospectively that might be critical to developing a SUDEP risk algorithm.

May 2, 2022

Fenfluramine Seems Effective for Lennox-Gastaut Syndrome

Among patients with Lennox-Gastaut syndrome (LGS), the percentage reduction in the frequency of drop seizures is greater with fenfluramine versus placebo, according to a study published online May 2 in JAMA Neurology.

May 2, 2022

The Brain ‘Learns’ to Have Seizures More Efficiently and Frequently Over Time, Mouse Study Shows

Featuring the research of former CURE Epilepsy grantee Dr. Juliet Knowles. Calculus. Ballroom dancing. The words to your favorite song. There’s practically no limit to what your brain can learn. But a new study suggests that the same process that allows you to hold onto new information and skills could also make certain neurological diseases worse.

April 29, 2022

Zeroing in on a New Treatment for Autism and Epilepsy

Children with Dravet syndrome, a severe form of epilepsy that begins in infancy, experience seizures, usually for their entire life. They are at high risk of sudden unexpected death in epilepsy (SUDEP) and can also develop intellectual disability and autism. Available treatments typically fail to improve these symptoms.

April 26, 2022

Is Breastfeeding Safe for Infants of Women With Epilepsy on Antiseizure Medication?

“The studies included in this review have shown that many ASMs were excreted into breastmilk in high concentrations,” the researchers said. “However, the majority of these ASMs did not produce significant adverse effects that warrant discontinuation of breastfeeding.”

April 25, 2022

Recurrence Rates and Risk Factors for Seizure Recurrence Following Antiseizure Medication Withdrawal in Adolescent Patients with Genetic Generalized Epilepsy

anti-seizure medication withdrawal at ?16?years of age and a diagnosis other than juvenile absence epilepsy may be independent risk factors for seizure recurrence after drug withdrawal in adolescent patients.

April 25, 2022

Hippocampal Position and Orientation as Prognostic Biomarkers for Post-Traumatic Epileptogenesis – an Experimental Study in Rat Lateral Fluid-Percussion Model

We demonstrate that assessment of TBI-induced hippocampal deformation by clinically translatable MRI methodologies detects subjects with prior TBI as well as those at high-risk of PTE, paving the way towards subject stratification for antiepileptogenesis studies.

April 22, 2022

Clemizole and Trazodone are Effective Antiseizure Treatments in a Zebrafish Model of STXBP1 Disorder Featuring the Work of Former CURE Epilepsy Grantee Dr. Scott Baraban

The present study by CURE Epilepsy grantee Dr. Scott Baraban extends this approach to a preclinical zebrafish model representing STXBP1-related disorders, and suggests that future clinical studies may be warranted.

April 21, 2022

CURE Epilepsy Discovery: Preventing Post-Traumatic Epilepsy May be Possible by Inhibiting Two Inflammation-Based Signaling Pathways

For his CURE Epilepsy “Prevention of Acquired Epilepsies” grant, Dr. Xiaoming Jin and his team sought to understand the role of two related signaling pathways called TLR4 and RAGE, in the development of post-traumatic epilepsy (PTE) following brain injury in mice.

April 20, 2022

Whole-Brain Preclinical Study Illuminates How Epileptic Seizures Originate

New evidence from a zebrafish model of epilepsy may help resolve a debate into how seizures originate, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. The findings may also be useful in the discovery and development of future epilepsy drugs.

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