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September 24, 2021

Reasons For Not Having Epilepsy Surgery

This study was undertaken to determine reasons for adults with drug-resistant focal epilepsy who undergo presurgical evaluation not proceeding with surgery, and to identify predictors of this course.

September 24, 2021

A Possible New Pathway for Treating Epileptic Seizures in Patients with Autism

Autism affects about 2% of children in the United States, and about 30% of these children have seizures. Recent large-scale genetic studies revealed that genetic variants in a sodium channel, called voltage-gated sodium channel Nav1.2, is a leading cause of autism. Overactive sodium channels in the neuron cause seizures.

September 23, 2021

Blocking Receptor for Advanced Glycation End Products (RAGE) or Toll-Like Receptor 4 (TLR4) Prevents Post-Traumatic Epileptogenesis in Mice

RAGE and TLR4 signaling are critically involved in posttraumatic epileptogenesis. Blocking these pathways early after traumatic brain injury is a promising strategy for preventing posttraumatic epilepsy.

September 22, 2021

Drug-Resistant Epilepsy: Drug Target Hypothesis and Beyond the Receptors

This review presents different conditions, such as epigenetic mechanisms and protein-protein interactions that may result in alterations of diverse drug targets using different mechanisms. These novel conditions represent new targets to control DRE.

September 22, 2021

Clinical Factors Associated with Work Disability in Epilepsy: A Cross-Sectional Study at a Tertiary Referral Hospital

The impact of epilepsy on work disability remains unclear. The aim of this study was to determine the percentage of patients with epilepsy who are unemployed or on temporary or permanent disability leave and to analyze associated clinical factors.

September 21, 2021

The Efficacy, Safety and Outcomes of Brain-Responsive Neurostimulation (RNS® System) Therapy in Older Adults

Responsive neurostimulation is approved in patients above 18 years of age with drug resistant focal epilepsy. We aimed to investigate whether RNS outcomes and safety varied based on age.

September 21, 2021

Psychiatric Disorders, Depression and Quality of Life in Patients with Psychogenic Non-Epileptic Seizures and Drug Resistant Epilepsy Living in Argentina

Higher psychiatric comorbidity with poorer quality of life were found in psychogenic nonepileptic seizures patients compared to drug resistant epilepsy. However, depression comorbidity negatively affected the quality of life in both groups.

September 17, 2021

Confirmation of Infantile Spasms Resolution by Prolonged Outpatient EEGs

There is no consensus on the type or duration of the post-treatment EEG needed for assessing treatment response for infantile spasms (IS). We assessed if outpatient electroencephalograms (EEGs) are sufficient to confirm infantile spasms (IS) treatment response.

September 16, 2021

Early-Onset Eyelid Stereotypies are a Frequent and Distinctive Feature in Dravet Syndrome

We propose that this movement disorder, namely 'eyelid stereotypies', might be an early motor trait of SCN1A-associated Dravet syndrome.

September 15, 2021

Epilepsy Centers in China: Current Status and Ways Forward

China has the largest population of patients with epilepsy worldwide, which imposes a heavy burden on the public and health care systems. Several epidemiological surveys on epilepsy have been performed in China.

September 15, 2021

Neuron-specific Mitochondrial Oxidative Stress Results in Epilepsy, Glucose Dysregulation and a Striking Astrocyte Response

Mitochondrial superoxide (O2 ?) production is implicated in aging, neurodegenerative disease, and most recently epilepsy. Yet the specific contribution of neuronal O2 ? to these phenomena is unclear.

September 14, 2021

Knowledge, attitude, and barriers for epilepsy surgery: A survey among resident doctors in a tertiary care center in India

A substantial number of participants lacked the basic knowledge of drug resistant epilepsy and epilepsy surgery. Lack of knowledge was perceived to be the commonest barrier for epilepsy surgery.

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