Although patient-specific variables were the primary determinant of seizure outcomes, cross-national disparities also contribute to heterogeneities in outcomes for patients with drug-resistant epilepsy.
The new results indicate that Early Infantile Epileptic Encephalopathy 35 (EIEE35), a neurological disorder characterized by epileptic seizures and associated with deficiency of ITPA, may involve cell membranes becoming more excitable because of depolarization caused by ITPA deficiency.
Perceived increases in seizures, reluctance to go to hospital and cancelled investigations are likely to impact on epilepsy management. The wider psychosocial impact is also likely to be significant with increases in child and caregiver mental health problems in an already vulnerable group.
Lack of health professionals and non-adherence to conventional epilepsy treatment are strongly associated with the use of Complementary and Alternative Medicine in the Middle East and North Africa (MENA) region.
Availability remains very low and phenobarbital, which is the most available and affordable AED was the worst in terms of quality. A drug policy addressing epilepsy treatment gap would reduce these barriers.