Pediatric Epilepsy
Certain structures within the brains of children with Angelman syndrome were altered compared with unaffected children of the same age, an MRI study concluded.
A decision tool using a small number of historical clinical features accurately predicts the probability of epilepsy. In indeterminate cases, AI-assisted EEG helps resolve uncertainty. This tool holds promise for use by healthcare workers without specialty epilepsy training if validated in an independent cohort.
Pediatric Epilepsy
Differences in sense of control, cognitive inhibition, and selective attention in pediatric functional seizures (FS) versus matched controls implicate these as potential novel treatment targets. Retraining and Control Therapy (ReACT), which targets these factors, has been shown in a randomized controlled trial to be effective in improving pediatric FS with 82% of patients having complete symptom remission at 60 days following treatment.
The study, published in the journal Science, found that when the molecules in the gel come in contact with enzymes inside an animal’s body, they become electrically conductive. This method could one day lead to better treatments for people with neurological conditions like Parkinson’s and epilepsy by letting scientists stimulate areas of the body with an external voltage.
Seizures can be predicted more than 30 minutes before onset in patients with temporal lobe epilepsy, opening the door to a therapy using electrodes that could be activated to prevent seizures from happening, according to new research from UTHealth Houston.
“Our data, therefore, demonstrates that brain over-activation could be causing both seizures and social deficits in this syndrome, and that too much PRRT2 is responsible for this,” Forrest said.
In preclinical studies, BMB-101 showed a protective effect against seizures in a zebrafish model of Dravet syndrome and in two rodent models of seizures. Also, repeated dosing of BMB-101, for nearly a month, was deemed safe and well-tolerated in mice and dogs.
The data were collected from a cross-sectional large study, using two structured questionnaires for headache and epilepsy features, fulfilled by neurologists.
University of Iowa biologists have definitively linked the brain’s immune system to epilepsy.
