Pediatric Epilepsy
In children with cerebral palsy, particular attention should be paid to the early identification and treatment of comorbid epilepsy.
SUDEP
Most child neurologists do not follow the current SUDEP Clinical Practice Guideline regarding SUDEP discussion. Reading the SUDEP Clinical Practice Guideline was a frequently cited reason among respondents who reported a recent change in discussion practice.
Most respondents had stable epilepsy during lockdown, and prior adoption of protective measures against general infection might have contributed to avoiding COVID-19 infections. However, behavior disorder worsened in over one-third of patients.
We have developed a mouse model of severe, refractory cortical-onset status epilepticus, consisting of convulsions merging into a coma, EEG patterns of cortical seizures, and injury, with evidence of widespread neocortical edema and damage.
Pediatric Epilepsy
A multiple stakeholder group developed clinical common data elements (CDEs) for routine care of children with epilepsy. Clinical CDEs are foundational for learning health care systems, a data?driven approach to health care focused on continuous improvement of outcomes.
In our traumatic brain injury model, tracking changes in non-rapid eye movement delta power distinguishes controlled cortical impact acutely and animals that will eventually develop post-traumatic epilepsy (PTE), but further work is necessary to identify sleep biomarkers of PTE.
The risk of increased seizures to pregnant women with epilepsy is no different to that of non-pregnant controls, as long as they have their medication levels monitored.
SUDEP
The study provided a deeper understanding of molecular, cellular, and network-level operations of the identified regulators that lead to cardiac changes in epilepsy.
Pediatric Epilepsy
The study concludes that knowing the child well and understanding the usual behavior of the child is crucial to seizure recognition.
