“Our data, therefore, demonstrates that brain over-activation could be causing both seizures and social deficits in this syndrome, and that too much PRRT2 is responsible for this,” Forrest said.
In preclinical studies, BMB-101 showed a protective effect against seizures in a zebrafish model of Dravet syndrome and in two rodent models of seizures. Also, repeated dosing of BMB-101, for nearly a month, was deemed safe and well-tolerated in mice and dogs.
The data were collected from a cross-sectional large study, using two structured questionnaires for headache and epilepsy features, fulfilled by neurologists.
University of Iowa biologists have definitively linked the brain’s immune system to epilepsy.
The relationship between ASM taper strategy, seizure timing and severity remains unclear. In this study, we developed and validated a pharmacokinetic model of total ASM load and tested its association with seizure occurrence and severity in the EMU.
“This could benefit so many children who can’t control epilepsy with drugs, which represents between 20 and 30% of children suffering from epilepsy,” said Christos Papadelis, senior author, who also serves as the director of research in the Jane and John Justin Neurosciences Center at Cook Children’s Health Care System.
Pediatric Epilepsy
In paediatric epilepsy, the evidence of effectiveness of antiseizure treatment is inconclusive for some types of epilepsy. As with other paediatric clinical trials, researchers undertaking paediatric epilepsy clinical trials face a range of challenges that may compromise external validity.
Pediatric Epilepsy
Researchers retrospectively reviewed the cases of 37 children and young adults with drug-resistant epilepsy who had undergone brain surgery at Boston Children’s Hospital. Their work concluded that noninvasive techniques to prepare for surgery could work better than existing, invasive methods.
Funding opportunities, workshops on epilepsy and PTE, and more in this Researcher Update.
