Pediatric Epilepsy
In this trial, EPIDIOLEX, when added to the patient’s current treatment, achieved the primary endpoint of reduction in convulsive seizures for both dose levels with high statistical significance compared to placebo.
Patients with temporal lobe epilepsy are more likely to experience negative-valence self-conscious emotions to a higher extent and positive self-conscious emotions to a lesser extent.
Pediatric Epilepsy
In comparison with normal neurocognition, subjects with lower childhood neurocognition are less likely to enter seizure remission. However, normal neurocognition does not guarantee complete remission or prevent premature death in some individuals with childhood onset epilepsy.
Pediatric Epilepsy
Only about one-quarter of children with absence epilepsy in this study became seizure free with levetiracetam. Lack of seizure control requiring continued dose escalation should prompt early consideration of a therapeutic medication transition.
Genetics
Scientists at the UNC School of Medicine have found evidence that genetic therapy may prevent the enhanced seizure susceptibility.
Pediatric Epilepsy
Organoids promise hope of a cure for illnesses ranging from childhood epilepsy to Alzheimer’s.
Pediatric Epilepsy
The ERGENT program provides free-of-charge genetic testing to babies who have features suggestive of a genetically-caused epilepsy.
Genetics
Advances in the ‘omics’, genetic epilepsy models and deep-phenotyping techniques have revolutionary translational research potential that can bring precision medicine to the forefront of clinical practice in the coming decade.
The use of predictive AI models may ensure patients with predicted drug-resistant epilepsy receive specialist care with potentially more aggressive therapeutic interventions from diagnosis, to help reduce the serious sequelae of drug-resistant epilepsy.
