Genetics
Results from a genome-wide mega-analysis show an enrichment for monogenic epilepsy genes as well as known targets of antiepileptic drugs. Using SNP-based heritability analyses, researchers disentangle both the unique and overlapping genetic basis to seven different epilepsy subtypes.
A history of intolerable adverse drug reactions has a large impact on the tolerability of future antiepilepsy drug regimens.
Genetics, Pediatric Epilepsy
Research finds when a "poison" exon on the SCN1A gene is incorporated, it prematurely cancels the production of a crucial protein, which disrupts neural function leading to seizure disorders.
Pediatric Epilepsy
Children with epilepsy and febrile seizures—with and without concomitant epilepsy—are at increased risk of developing a broad range of psychiatric disorders in later life.
Teens and adults with epilepsy are at higher risk for depression than the general population and should be screened regularly and provided therapy if needed.
This study finds that Perampanel at low doses and as a first add-on treatment is a good option for patients with focal and generalized epilepsy.
Patients taking certain dosages of fenfluramine showed significant and clinically meaningful improvements in behavior regulation, emotion regulation, and planning and organization.
Eslicarbazepine acetate ESL was effective and well tolerated in a small subgroup of patients with post-stroke epilepsy, researchers state,
The open-label ARTEMIS-2 study supports the long-term safety of repeated usage of midazolam nasal spray in the outpatient setting to treat seizure clusters.
