Three FDA-approved drugs designed to treat other conditions significantly reduced seizure-like movement in zebrafish.
Discover the latest about what's happening at CURE and in our community in the December 2018 CURE Update from Chief Scientific Officer, Laura Lubbers!
Pediatric Epilepsy
Study finds the Refractory Epilepsy Screening Tool for LGS may be a valuable clinical tool in identifying patients requiring further diagnostic evaluation for LGS.
Genetics
Results from a genome-wide mega-analysis show an enrichment for monogenic epilepsy genes as well as known targets of antiepileptic drugs. Using SNP-based heritability analyses, researchers disentangle both the unique and overlapping genetic basis to seven different epilepsy subtypes.
A history of intolerable adverse drug reactions has a large impact on the tolerability of future antiepilepsy drug regimens.
Genetics, Pediatric Epilepsy
Research finds when a "poison" exon on the SCN1A gene is incorporated, it prematurely cancels the production of a crucial protein, which disrupts neural function leading to seizure disorders.
Pediatric Epilepsy
Children with epilepsy and febrile seizures—with and without concomitant epilepsy—are at increased risk of developing a broad range of psychiatric disorders in later life.
Teens and adults with epilepsy are at higher risk for depression than the general population and should be screened regularly and provided therapy if needed.
This study finds that Perampanel at low doses and as a first add-on treatment is a good option for patients with focal and generalized epilepsy.