Pediatric Epilepsy
Study says stiripentol has better efficacy in Dravet syndrome (DS) patients with definite SCN1A mutations than in DS patients with variants of unknown significance and benign SCN1A mutations,
This first population?based study using the ILAE 2015 definition and classification of SE found an increase of incidence of 10% compared to previous definitions.
Pediatric Epilepsy
In this trial, EPIDIOLEX, when added to the patient’s current treatment, achieved the primary endpoint of reduction in convulsive seizures for both dose levels with high statistical significance compared to placebo.
Patients with temporal lobe epilepsy are more likely to experience negative-valence self-conscious emotions to a higher extent and positive self-conscious emotions to a lesser extent.
Pediatric Epilepsy
In comparison with normal neurocognition, subjects with lower childhood neurocognition are less likely to enter seizure remission. However, normal neurocognition does not guarantee complete remission or prevent premature death in some individuals with childhood onset epilepsy.
Pediatric Epilepsy
Only about one-quarter of children with absence epilepsy in this study became seizure free with levetiracetam. Lack of seizure control requiring continued dose escalation should prompt early consideration of a therapeutic medication transition.
Genetics
Scientists at the UNC School of Medicine have found evidence that genetic therapy may prevent the enhanced seizure susceptibility.
Pediatric Epilepsy
Organoids promise hope of a cure for illnesses ranging from childhood epilepsy to Alzheimer’s.
