Neurostimulation modalities are an effective treatment option for drug resistant epilepsy, with improving outcomes over time and few major complications. Seizure reduction rates among the three therapies were similar during the initial blinded phase.
More than 90% of children with Dravet syndrome have a pathogenic, or disease-causing, variant in the SCN1A gene, which makes the protein Nav1.1, a sodium channel that is important for the activity of seizure-suppressing cells called interneurons and, in particular, a subtype of interneuron called the parvalbumin interneuron.
Non-invasive techniques capable of localizing the seizure-onset zone could improve pre-surgical planning in patients with intractable epilepsy. We have demonstrated the ability of deep learning to identify the correct hemisphere of the seizure onset zone in TLE patients using RS-fMRI with high accuracy.
Multidisciplinary care involves all stages of disease management: diagnostics, specific or symptomatic, acute and chronic treatments, and integrated care that takes into account not only medical, but also manifold psychosocial, educational, vocational and other needs of patients and their caregivers.
For these patients, the study found that the patients who received VNS, when used with anti-seizure medications (ASM), had lower hospital costs compared to the use of ASM alone.
Ketogenic Diet
They observed that a reduction in the amount of energy led to an increase in the level of calcium in neurons, making them hyperexcitable. These dysfunctions could be corrected when mice were fed a ketogenic diet, which is rich in lipids and has been used since antiquity. This work is published in the journal eLife.
Background: To assess the functional involvement of the central nervous system (CNS) via quantitative electroencephalography (EEG) analysis in children with mild to moderate COVID-19 infection who were otherwise previously healthy children.
Objective: To calculate epilepsy-related direct, indirect, and total costs in adult patients with active epilepsy (ongoing unprovoked seizures) in Germany and to analyze cost components and dynamics compared to previous studies from 2003, 2008 and 2013.
Researchers from Otago and Okinawa Institute of Science and Technology Graduate University have developed a new system that uses specialized sound waves (above the frequency that we can hear) or light (above the wavelength that we can see) to release medication into specific areas of the brain to stop seizure activity.
