SUDEP
New research confirms that if spreading depolarization of neurons engages the brainstem, the result is fatal.
This study presents the first evidence for the effectiveness of fenfluramine in reducing seizure incidence, severity, and seizure-induced respiratory arrest susceptibility in a mammalian SUDEP model.
According to this retrospective analysis, higher concentrations of lactate and total protein as well as blood-brain barrier dysfunction are often seen after epileptic seizures vs mild pleocytosis and Ig synthesis.
According to this population-based study, seizures in neonates seemed to play an important role in the development of epilepsy, intellectual disability and headache when covariates were observed to be equal.
A triple-blind trial found a benefit for supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) among men and women with intractable seizures.
Regardless of seizure frequency, impaired awareness, cluster seizures, sleep-only seizures, and convulsive seizure were characteristics found to significantly influence injuries.
In absence epilepsy, mesio-temporal epilepsy, and some idiopathic childhood epilepsies, NREM sleep has a pivotal role in the development and course of the disorder.
There is a large body of evidence suggesting parasites could be a major preventable risk factor for epilepsy in low- and middle-income countries, according to this study.
The FDA has accepted for filing the New Drug Application (NDA) for cenobamate, an investigational antiepileptic drug being developed for the treatment of partial-onset seizures in adults.
