Genetics
Study finds that mice with a particular GABA-A receptor subunit mutation have increased neuroinflammation in multiple brain regions.
Pediatric Epilepsy
Three quarters of severe epilepsies of infancy could be assigned an epilepsy syndrome or "variant syndrome" at presentation.
Genetics
Researchers identified genes that may contribute to the shared genetic etiology between epilepsy and autism, which could eventually be used for personalized treatment and management.
Although patient-specific variables were the primary determinant of seizure outcomes, cross-national disparities also contribute to heterogeneities in outcomes for patients with drug-resistant epilepsy.
Genetics, Pediatric Epilepsy
The new results indicate that Early Infantile Epileptic Encephalopathy 35 (EIEE35), a neurological disorder characterized by epileptic seizures and associated with deficiency of ITPA, may involve cell membranes becoming more excitable because of depolarization caused by ITPA deficiency.
Perceived increases in seizures, reluctance to go to hospital and cancelled investigations are likely to impact on epilepsy management. The wider psychosocial impact is also likely to be significant with increases in child and caregiver mental health problems in an already vulnerable group.
The single most important factor associated with contracting COVID-19 is a close relative with this infection. Symptomatic COVID-19 does not seem to be more likely in patients with epilepsy.
Lack of health professionals and non-adherence to conventional epilepsy treatment are strongly associated with the use of Complementary and Alternative Medicine in the Middle East and North Africa (MENA) region.
Genetics
Catamenial seizures, also known as menstrual seizures since they are linked to a woman’s menstrual cycle and related hormone levels in the body, were seen in 17 Rett patients (22.1%).
