Working memory deficits are prevalent in childhood epilepsy. Working memory processing is thought to be supported by the phase of hippocampal neural oscillations. Disruptions in working memory have previously been linked to the occurrence of transient epileptic activity. This study aimed to resolve the associations between oscillatory neural activity, transient epileptiform events, and working memory in children with epilepsy.
SUDEP
Researchers have highlighted the similarities between SUDEP and Sudden infant death syndrome (SIDS) but perinatal risk factors such as those identified for SIDS, have not been assessed previously for SUDEP.
Prolonged and repetitive cycles of pharmacological coma, with midazolam or other general anaesthetics, is often the mainstay for seizure control in febrile infection-related epilepsy syndrome (FIRES). Here we present our experience of enteral lorazepam as an effective weaning substitute in midazolam-dependent patients.
The recurrent p.R1636Q variant represents one of the most common causes of early-onset SCN1A-related epilepsies with separate treatment and prognosis implications.
Genetics
We collated all the genes associated with all types of seizures/epilepsy in all species, and quantified the supporting evidence for each gene, by manually screening ~10,000 publications, and by extracting data from existing databases.
As a non-profit organization devoted to the health and well-being of people with epilepsy, CURE Epilepsy believes that access to comprehensive reproductive healthcare is critically important for people of childbearing age who have epilepsy.
Seizures are a common reason for calling emergency medical services. A lack of guidelines on prehospital treatment in Germany leads to high transportation rates and reduced confidence in decision making by professionals.
The study, “Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia,” was published in the International Journal of Molecular Sciences.
Featuring the work of CURE Epilepsy grantee Dr. Pavel Klein. Long-term use of Xcopri was safe and reduced seizures by more than 90% in adults with uncontrolled focal seizures, according to results of an open-label extension study published in Neurology.
