A round-up of top epilepsy research news from the past month.
Epilepsy and Alzheimer's Disease appear to be associated. People with Alzheimer’s disease have a high risk of developing seizures—more than 80 times the risk of people who don’t have Alzheimer’s.
Outcomes suggest an association of hypertension, diabetes, smoking, APOE ?4 allele number, activity level, and alcohol use with late-onset epilepsy.
Selective placement of stimulation electrodes along the corpus callosum could be used as a patient?specific treatment for cortical epilepsies.
In this cohort, the overall mortality of first?time nonhypoxic status epilepticus was >50%. Mortality of status epilepticus after discharge was substantially higher than in?house mortality and stabilized after 2 years.
Adjunctive perampanel demonstrated a favorable safety profile and long-term tolerability in Japanese patients with refractory partial-onset seizures for ?316 weeks.
A study found that thirty-eight percent of mothers of children with epilepsy had significant parenting stress.
A research team has determined perineuronal nets modulate electrical impulses in the brain, and that seizures can occur if the nets are dissolved.
Genetics
Recent studies in mouse models based on UBE3A gene replacement or reactivation in neurons hold great therapeutic potential, including for the treatment of epilepsy.
