Featuring the work of CURE Epilepsy Scientific Advisory Council member Dr. Vicky Whittemore and CURE Epilepsy grantee Dr. Kevin Wang.
We discuss the important elements that need to be considered for the proteomics, lipidomics and metabolomics methodologies, providing a rationale for the parameters that should be documented.
Children and adolescents with Dravet syndrome with walking difficulties commonly experience impairments in functional mobility and greater restrictions in daily life activities, a study suggests.
Genetics
Among data drawn from four unrelated MAE patients were seizure phenotypes (including EEG patterns) and whole-exome sequences (drawn also from the parents). Four different de novo SLC6A1 variants were found in the four patients, and for two of these, machine learning predicted destabilized forms of GAT1.
Mechanisms
Understanding the exact molecular mechanisms involved in the etiology of epileptogenic pathologies with or without tumor activity is essential for improving treatment of drug-resistant focal epilepsy.
In this month's update, our free reception during the 2022 AES Annual Meeting, a survey to aid multidisciplinary clinics for persons with epilepsy, and more!
Our October issue of Epilepsy Research News highlights a possible seizure prevention peptide, pregnancy and epilepsy, and possibly elevated epilepsy risk for bariatric surgery recipients.
The combination of the neuropeptide galanin analog 810-2 with levetiracetam suggests the potential for this galanin analog to be further developed as an add-on therapy for patients with epilepsy, particularly when co-administered with levatiracetam.
Neurology staff were unaware of a significant number of patients presenting with seizures, which is of concern in an already over-stretched department. This offers an opportunity to improve care for people with epilepsy.
The scientific community should develop standardized seizure first aid training programs for the general public and healthcare professionals alike.
