Although anti-epileptic drug withdrawal increases the likelihood for epileptic seizures, it did not prolong the seizure duration, nor did it increase the rate of secondary generalization in this study.
Pediatric Epilepsy
Researchers tested efficacy of a novel fusion peptide AQB-565 in a model of infantile spasms consisting of prenatal exposure to betamethasone and repeated postnatal trigger of spasms with N-methyl-d-aspartic acid (NMDA).
Bedside amplitude-integrated EEG possesses low sensitivity and specificity for detecting seizures compared with conventional EEG and may be prone to error in seizure classification in neonates
SUDEP
Significant tissue loss may shed light on SUDEP pathogenesis and prospectively detect patterns identifying those at risk.
This research team says their tool has the potential to improve the efficiency and rigor of preclinical research and therapy development using these models.
Research provides reassurance that taking ADHD medications won't raise risk of seizures in people with epilepsy.
Children with drug-resistant focal epilepsy and focal cortical dysplasia who undergo complete resection of Morphometric Analysis Program (MAP)-positive regions are more likely to experience seizure-free outcomes compared with children who receive no or partial resection.
Biomarkers such as high?sensitive troponin T (hsTNT), copeptin, and soluble urokinase plasminogen activator receptor (suPAR) may be helpful to identify cardiac stress after generalized convulsive seizures (GCS) in patients with refractory epilepsy.
A comprehensive review of the MRI characteristics in all reported patients with a FIRES diagnosis, describing the findings in the acute and chronic phases of the disease, and discussing possible pathogenesis and radiologic differential diagnoses.
