Despite expectations that circadian and sleep disruption related to daylight savings time transitions would increase the incidence of seizures, this study found little substantive evidence for such an association in this large, longitudinal cohort.
SUDEP
Findings show the conflicting perceptions, feelings, and thought processes that occur in learning about and deciding to discuss SUDEP as a healthcare provider, person with epilepsy, or family/friend of a person with epilepsy.
Efforts to improve medication self-management among children with epilepsy should include strategies to develop teaching skills among nurses delivering the discharge education.
Pediatric Epilepsy
Researchers state levetiracetam is probably a better option compared with carbamazepine to prescribe for children with Rolandic epilepsy.
Although anti-epileptic drug withdrawal increases the likelihood for epileptic seizures, it did not prolong the seizure duration, nor did it increase the rate of secondary generalization in this study.
Pediatric Epilepsy
Researchers tested efficacy of a novel fusion peptide AQB-565 in a model of infantile spasms consisting of prenatal exposure to betamethasone and repeated postnatal trigger of spasms with N-methyl-d-aspartic acid (NMDA).
Bedside amplitude-integrated EEG possesses low sensitivity and specificity for detecting seizures compared with conventional EEG and may be prone to error in seizure classification in neonates
SUDEP
Significant tissue loss may shed light on SUDEP pathogenesis and prospectively detect patterns identifying those at risk.
This research team says their tool has the potential to improve the efficiency and rigor of preclinical research and therapy development using these models.