2005

Gene Expression In Cortical Dysplasia

Brenda E. Porter, MD, PhD
Children’s Hospital of Philadelphia
 

Many children with hard to treat epilepsy have an abnormality called focal cortical dysplasia (FCD) in which, during brain development, neurons become disorganized and misalign. This study tries to understand which molecules in the cortical dysplasia neurons are different and how these differences cause epilepsy. The long term aim is to investigate possible means of “turning off” the cortical dysplasia neurons in the hope of fulfilling CURE’s goal of no seizures/no side effects.

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