2005

CURE Epilepsy Award, Funded by the Hope Foundation

Gene Expression In Cortical Dysplasia

Brenda E. Porter, MD, PhD
Children’s Hospital of Philadelphia
 

Many children with hard to treat epilepsy have an abnormality called focal cortical dysplasia (FCD) in which, during brain development, neurons become disorganized and misalign. This study tries to understand which molecules in the cortical dysplasia neurons are different and how these differences cause epilepsy. The long term aim is to investigate possible means of “turning off” the cortical dysplasia neurons in the hope of fulfilling CURE’s goal of no seizures/no side effects.

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More Research in the Area of Genetics

Gene Therapy for the Catastrophic Type 1 Progressive Myoclonus Epilepsy (EPM1)

Berge Minassian, MD

The University of Texas Southwestern Medical Center

The Joseph Gomoll Foundation
Tribute

Convergence of High Frequency Oscillations with Genetic and Epigenetic Profiles in Epileptic Networks: Towards Novel Diagnostics in Focal Epilepsies

Gemma Carvill, PhD

Northwestern University

Multimodal Profiling of Neuronal Morphology, Physiology and Gene Expression in Focal Cortical Dysplasia

Cathryn Cadwell MD, PhD

University of California, San Francisco

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