Glia Activation And Vascular Changes As Biomarkers Of Epileptogenesis: MRI/MRS Longitudinal Studies In Experimental Models

Traumatic brain injury may result in activation of glial cells along with production of inflammatory molecules and damage to the blood-brain barrier; increasing the risk for the injured person to develop epilepsy. In experimental models of epilepsy, glia activation and blood-brain barrier breakdown contribute to seizure precipitation and recurrence. Using in vivo MRI and MRS imaging techniques combined with EEG analysis and behavioral testing in animals, Dr. Ravizza will evaluate whether blood-brain barrier damage and glia activation after brain injury predict the development of spontaneous seizures and cognitive dysfunction. This information may provide not only clinically relevant prognostic tools, but also novel targets for developing effective strategies to prevent seizures and/or cognitive dysfunction following traumatic brain injury.