In Vivo Time-Lapse Imaging Of An Epileptogenic Focus In Post-Traumatic Epilepsy

In this three-year project, Dr. Mizrahi will study the changes within the brain that underlie the development of post-traumatic epilepsy in mice. He will use live imaging techniques in a mouse model of post-traumatic epilepsy to learn how brain cells react when post-traumatic epilepsy develops. These experiments will provide a direct view, at high resolution, of the actual dynamics of the development of epilepsy. Such in vivo experiments may lead to the discovery of new biological mechanisms that lead to epilepsy after brain injury.