Local Dynamics And Dialog Among Hippocampo-Entorhinal Networks In A Model Of Temporal Lobe Epilepsy In Vivo

Temporal lobe epilepsy is the most common form of epilepsy in adults and many remain resistant to drug treatment. Besides seizures, patients often have severe cognitive deficits, as well. Our assumption is that the deficient cognitive functions and seizure generation emerge from an alteration of the communication between temporal neuronal networks. In order to help CURE achieve the goal of “no seizures and no side effects”, we seek to understand these complex mechanisms using an in vivo approach. Our project aims to decipher the communication between neuronal networks in an animal model of temporal lobe epilepsy. We will use high-density electrodes to read the activity of large neuronal networks in an effort to determine whether the alterations detected might contribute to seizures and/or to cognitive deficits.