Medicines in Development as Neuro-Immune Therapies for Epilepsy (MIDNITE)
University of Utah
2024
Cameron Metcalf, PhD & Mingnan Chen, PhD
About 30% of epilepsy patients don’t respond to current treatments. The immune system plays an important role in epilepsy, but more research is needed to understand whether targeting immune cells could be a new way to prevent seizures. This project seeks to better understand changes in the immune system that can help identify new therapy targets. Drs. Metcalf and Chen will use a model of Temporal Lobe Epilepsy (TLE) to study specific immune cell populations and target certain immune cell types as a proof-of-concept approach to prevent seizures and/or reduce disease severity.
