Molecular Mechanism Of Limbic Epilepsy In A New Genetic Mouse Model

Mouse models of epilepsy have contributed to the discovery of human epilepsy genes and all antiepileptic drugs to date. Dr. Yang has identified a new gene (BRUNOL4), which plays a role in a type of epilepsy originating in the temporal lobe. He will investigate how a deficiency in this gene leads to recurrent seizures in mice, and evaluate novel anti-epileptic therapies using this new mouse model of epilepsy.