Pathogenesis Of Cortical Lesions In A Model Of Tuberous Sclerosis
Arnold R. Kriegstein, MD, PhD
University of California, San Francisco
Sixty to ninety percent of patients with tuberous sclerosis have difficulty controlling epilepsy due to genetically abnormal progenitor cells, which hamper proper cortical development. In this study, observation of the proliferation and migration of these cells will add valuable insight into how these gene defects influence cortical development and on potential new therapies.