2015

Innovator Award

Pericyte PDGFRB Signaling During Seizures: Characterization Of A New Mechanism Of Disease

Nicola Marchi, PhD
CNRS Delegation Regionale Languedoc Roussillon, France
 

Seizures remain difficult to control in a significant percentage of patients. Increasing evidence indicates that epilepsy can be caused by vascular disease in the brain and that abnormal neuronal activity is linked to blood vessel dysfunction in the brain. Targeting the damaged brain vasculature could represent a therapeutic approach to end seizures. We propose that a key brain vasculature receptor called PDGFRb regulates the brain's blood flow response to seizures, and we will explore whether modulation of the receptor using specific medications can stop seizures.

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