Post-Traumatic Epileptogenesis: Development And Use Of Animal Models For Identification Of Molecular Mechanisms And Surrogate Markers

Traumatic brain injury (TBI) is a major cause of acquired focal epilepsy in adults. This projects aims at developing new, clinically relevant animal models that can be used to investigate molecular mechanisms of epileptogenesis after TBI and to test novel candidate treatments for prevention of post-traumatic epilepsy (PTE). The second goal is to find surrogate markers that could identify the subjects who are at risk of developing PTE by using magnetic resonance imaging.