Memory loss is a major contributor to disability for individuals with seizures arising from the mesial temporal lobe of the brain. Dr. Gross will test whether electrical stimulation of an important nerve pathway, the septohippocampal system, which connects the frontal lobe to the temporal lobe, can both control seizures and improve memory. Electrical stimulation will be done using an animal model of hippocampal epilepsy, a valid model of epilepsy that also shows memory dysfunction similar to that found in individuals with epilepsy. Positive results would pave the way for a clinical pilot study of electrical stimulation in individuals with mesial temporal lobe epilepsy as a means to control seizures and improve memory.
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