Targeting Epileptogenic Effects of Subarachnoid Blood in TBI
A major challenge to the study of post-traumatic epilepsy (PTE) is that there are vast differences in the types of traumatic brain injury (TBI) that can lead to epilepsy, including blows to the head, blasts, and penetrating brain injuries. To better understand and prevent epilepsy following TBI, it is essential to understand common changes in the brain that might lead to PTE.
Dr. Jeffrey Loeb and his team have chosen to focus on studying subarachnoid hemorrhage, or bleeding in the space between the brain and the tissue surrounding the brain, a phenomenon that commonly occurs following a brain injury. In fact, in both animals and humans, subarachnoid hemorrhage occurs in almost all severe TBIs and is known to produce seizures. By examining patients with subarachnoid hemorrhage and an animal model of subarachnoid hemorrhage, the Loeb team will use methods such as MRI and EEG to characterize the development of PTE with the aim of understanding and predicting who is at risk for developing this condition and identifying potential treatment strategies.