2007

Multidisciplinary Awards

The Role Of CREB In Epileptogenesis

Julie Blendy, PhD - Brenda Porter, MD
University of Pennsylvania Children’s Hospital of Philadelphia
 

The goal of this project is to identify cellular and molecular changes that contribute to the development of epilepsy after an injury to the brain. A large number of molecular, cellular and physiologic changes have been described following brain injury, including neuronal cell loss, and changes in the expression of genes and proteins. Dr. Porter, an epilepsy researcher, and Julie Blendy, a pharmacologist will examine whether one of the master regulators of neuronal survival and gene expression, CREB, is necessary for animals to develop epilepsy after brain injury.

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