Development of novel strategies to more efficiently and safely cure epilepsy is urgent for both clinical and basic neuroscientists. Chandelier cells are the most powerful inhibitory neurons, and they can be useful for a cell transplantation therapy to reduce seizures. First, we will test if transplantation of chandelier cells into an animal model of epilepsy can reverse the seizure phenotype. Second, we will identify genetic programs that specifically lead to the development of chandelier cells. Our research will provide key insight into future clinical applications of cell transplantation.
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