Brief Summary: This study will investigate whether a Vagal Nerve Stimulator (VNS) causes measurable desynchronization and reduces epileptiform activity, such as spikes and seizures, in electrocorticograms (ECOGs) recorded by a Responsive Neurostimulator (RNS) in patients who have both devices implanted.
Specific aims of the study:
- Evaluate the change in frequency of epileptiform discharges during active VNS stimulation compared to interstimulation baseline periods
- Evaluate the change in frequency of seizures during active VNS stimulation compared to interstimulation baseline periods
- Evaluate the change in the number of RNS activations during active VNS stimulation compared to interstimulation baseline periods
- Evaluate the change in synchronization of background ECoG (electrocorticogram) during VNS stimulation compared to interstimulation baseline periods
Estimated study start date: August 1, 2018
Estimated study completion date: December 1, 2018
Eligibility Criteria:
Ages Eligible for Study: 18 Years to 75 Years (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes
Sampling Method: Non-Probability Sample
Inclusion Criteria:
- A patient of the University of Colorado Hospital Epilepsy clinic;
- Have had either VNS and/or RNS implanted;
- Age 18 years to 75 years.
Exclusion Criteria:
- Not capable of making a medical decision;
- Unable to comprehend study details, or
- Unable to adequately communicate secondary to intellectual or language barrier.