CURE seeks novel research projects of relevance to the prevention, treatment and cures of acquired (post-insult) epilepsies including: (1) the cellular, molecular, and systems-level understanding of the underlying pathogenic mechanisms; (2) specific approaches to modify the development of acquired epilepsy; (3) animal models of acquired epilepsy; and (4) investigations of the impact, natural history, and epidemiology of acquired epilepsy. For the purposes of this program, "acquired epilepsies" are defined as epilepsies which result from injury to the brain, including traumatic brain injury, stroke, infection, and brain tumor. CURE strongly encourages collaborative projects, specifically those that introduce investigators and expertise from fields outside of epilepsy.

Eligibility: This award is available to both established and early career investigators exploring cutting-edge approaches to curing epilepsy. International applicants are welcome. Researchers who serve on CURE’s Scientific Advisory Board are ineligible to apply for or sponsor a grant for the duration of their term. All materials must be submitted in English.

* Generally, early career investigators are university faculty at the assistant professor level (or hold an equivalent position in a non-university research organization). Established investigators are university faculty at the associate professor level or above.

Budget: Requests may be made for up to $250,000 over 2 or 3 years.

Letter of Intent: All applicants must submit a Letter of Intent (LOI). The LOI should succinctly outline the hypothesis to be tested, the specific aims and provide a brief description of the research plan. All LOIs are evaluated by scientific reviewers and the Research Review Board, with the final decisions as to who will be invited to submit formal proposals made by the CURE Board of Directors.

All letters of intent must be submitted through proposalCENTRAL (https://proposalcentral.altum.com) by Tuesday, January 22, 2013 at 9:00pm, ET. In order to begin an application, applicants will need to create a professional profile, if one does not already exist. Please fill in all required fields in the online application form.

Instructions for each section of the online application:

1. Title Page: Enter proposal title (maximum 150 characters, including spaces).
2. Enable Other Users to Access this Proposal: Use this optional section to grant access to a collaborator or co-investigator.
3. Applicant/PI: This section should auto-populate from the applicant’s professional profile. Double-check that the information is complete and correct. If it is not, click Edit Professional Profile to update the information. Indicate whether you are an early career or established investigator.
4. Institution & Contacts: Information should auto-populate from applicant’s profile.
5. Collaborators/Co-investigators: Please enter information for any co-investigators or collaborators, if applicable.
6. Letter of Intent: Upload PDF of Letter of Intent according to the guidelines outlined below.
7. Validate: The system will check for required components that have not been completed. Applicants will not be able to submit until all required components are completely filled out.

Submit: Make sure to hit Submit after your application has been validated!

Letter of Intent Instructions:

In your uploaded letter of intent, please provide the following in a maximum of 2 pages:

1. How does this project address CURE’s mission of ultimately achieving No Seizures/No Side Effects? (1,000 characters maximum)
2. Provide a brief description of the research plan that succinctly outlines the hypothesis to be tested and the specific aims.

Formatting Guidelines:

• Type font: 12 point, 10 pitch
• Type density: No more than 15 characters per inch (including spaces). For proportional spacing, the average for any representative section of text should not exceed either 15 characters per inch or 114 characters per line.
• Spacing: Single-spaced between lines of text, no more than five lines of type within a vertical inch.
• Margins: Minimum of 0.5-inch top, bottom, right, and 1-inch left.

For questions, please contact Julie Milder at the CURE office, 312.255.1801, or email julie@cureepilepsy.org.

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