This conference will bring together a diverse group of physicians and scientists to discuss critical questions about late-onset unexplained epilepsy (LoUE), focusing on new research approaches and recent scientific advances to address these challenges. The event will bring together leading experts in the fields of epilepsy, stroke, vascular disease, and neurodegeneration to foster multidisciplinary collaboration and shared knowledge. Conference topics will range from animal studies to longitudinal clinical and epidemiologic studies.