Functional Integration of Ectopic Granule Cells in a Rat Model of Tle

Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that is typified by seizures that are unresponsive to anticonvulsant drugs and often requires surgical intervention. Current medications are solely directed at seizure management and do nothing to treat the underlying disease. Therefore, the experiments in this proposal are focused on the early events that occur during the development of epilepsy. In addition to providing critical insight into the basic mechanisms that contribute to the development of epilepsy, these preclinical studies may lead to novel therapies directed at preventing the development of epilepsy after brain insults.