Interrater agreement in categorizing drug responsiveness status and treatment outcomes according to the International League Against Epilepsy (ILAE) definition of drug-resistant epilepsy is moderate to almost perfect, according to new study results published in Epilepsia.
Researchers consecutively enrolled 1053 patients with focal epilepsy (mean age, 44.5±14.2) who met ILAE criteria for drug resistance. Patients had been treated at 43 centers and were followed-up prospectively for 18 to 34 months. Individual investigators and 2 rotating members of a 16?member expert panel retrospectively reviewed and categorized treatment outcomes for all antiepileptic drugs (AEDs) used up to time of enrollment as well as outcomes of newly introduced AEDs at enrollment. Cohen’s kappa (k) statistics were used to test interrater agreement.