Talk summary: Individuals with epilepsy, particularly those with uncontrolled epilepsy, are at a much greater risk of premature death than those without. In fact, the standardized mortality ratio in those with epilepsy is between 2 and 3. In the UK, the most common cause of epilepsy-related death is due to Sudden Unexpected Death in Epilepsy (SUDEP), which accounts for up to one-fifth of deaths in some series. SUDEP is more common in those with frequent convulsive seizures (particularly nocturnal seizures) and in those with drug-resistant epilepsy. While the causes of SUDEP are unknown, the most commonly suggested underlying mechanisms are cardiac arrhythmias, respiratory depression and “cerebral shutdown.” Because no preventative measures currently exist, an understanding of SUDEP risk factors, potential mechanisms and the effectiveness of preventative measures is essential. To this end, there are a multitude of opportunities available in the field of SUDEP research and these opportunities will be interactively discussed during the presentation.
September 18, 2019
High-Resolution Mapping Shows Differences in Epilepsy Prevalence Depending Upon Socioeconomic Status in an Urban Area in Sweden
This team’s objective was to compare epilepsy prevalence and emergency medical service (EMS) assignments for seizures in areas of different socioeconomic standings in the urban area of Gothenburg.
September 18, 2019
Review Suggests that Improved Management of Pregnancy in Women with Epilepsy Living in Sub-Saharan Africa is Needed
This review underscores the need for contextualized evidence-based clinical guidelines and a collaborative approach to treat women with epilepsy in sub-Saharan Africa.
September 17, 2019
Scientific Method Called “dCas9-Based Scn1a Gene Activation” Lessens Febrile Seizures in Dravet Syndrome Mice
The research team claims that their results pave the way for exploiting dCas9-based gene activation as an effective and targeted approach in Dravet syndrome and other disorders resulting from altered gene dosage.