Funded by the Christopher Donalty and Kyle Coggins Memorial Award
Prevention Of SUDEP By Serotonergic Agents In DBA/1 Mice
Carl Faingold, PhD
Southern Illinois University School of Medicine
Dr. Faingold has developed a new animal model of human sudden unexpected death in epilepsy (SUDEP), DBA/1 mice. These animals show generalized seizures and then stop breathing if not resuscitated, which is common in human SUDEP. They found that drugs that increase the level of a neurochemical (serotonin) in the brain will prevent SUDEP in these mice. The current study will examine if new drugs that have a more selective effect on serotonin will prevent the respiratory arrest that follows seizures in these mice.