Epilepsy results from excessive, abnormal brain activity caused by an imbalance between excitatory and inhibitory signals. A special type of inhibitory cell, called CCK interneurons, helps maintain this balance. In epilepsy, this balance is disrupted, especially in a part of the brain called the hippocampus.
This project will study how epilepsy changes the way CCK interneurons work and whether fixing their activity can reduce seizures and improve memory, motivation, and behavior. Because these cells respond to the body’s cannabinoid system, they may be a promising target for future treatments.
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