Infantile Spasms
This new approach could potentially reduce or even eliminate the associated neurodevelopmental and cognitive effects of this devastating disorder without the side effects of the currently available treatments.
Mechanisms
This research paves the way for future studies that may identify ways to prevent harmful changes in myelination to treat some forms of epilepsy.
SUDEP
Dr. Lacuey hopes to use these valuable results to develop a device that will stimulate critical areas of the brain following seizures to enhance breathing and avoid its cessation, thereby preventing SUDEP.
Post-Traumatic Epilepsy
Data from Dr. Jin’s lab further validate the roles of HMGB1, its receptors TLR4 and RAGE, and their downstream inflammatory pathways in the PTE process itself, including cellular level changes, and how blocking either of these pathways may one day prevent PTE.
SUDEP
These novel results suggest the critical role of the superior colliculus in seizures that may lead to SUDEP. The results also strengthen the understanding of the sequence of events that may cause SUDEP.
This study revealed that changes in the Wnt and mTOR signaling pathways, and the changes in glucose metabolism and neurotransmitter balance may lead to the progression of epileptogenesis and the development of epilepsy
Tech/AI
The early learnings achieved through the CURE Epilepsy funded research have carried over into the development of “next-generation” implantable therapeutic devices.
Infantile Spasms
Rapamycin appears to be an effective treatment for IS and that short-term administration early in life and during the peak of spasms can prevent future seizures in adulthood and even improve cognitive outcomes.
Sleep, SUDEP
Previous research has revealed that disruptions in ANS function related to a seizure event are marked by diminished control of these three body processes, but the precise nature and mechanisms of these weakened responses are not clear.
