Closed-Loop Resynchronization of Epileptic Circuits

Dr. Shuman and his team are attempting to understand the specific activity patterns of cells in the brain that produce seizures and cognitive deficits in epilepsy. Their recent work has shown that in epileptic mice, cells that provide neuronal inhibition are active at the wrong times. For this project, Dr. Shuman is using state-of-the-art technology to make these inhibitory cells fire at the correct times and see if this can reduce seizures and improve memory. This study has the potential to lead to new treatment options for people with epilepsy based upon correcting the firing patterns of inhibitory cells in their brains.

The CURE Epilepsy Research Continuity Fund will help Dr. Shuman replace laboratory supplies and continue this work after a period of COVID-19 related laboratory closure.