It is known that increased brain temperatures can trigger seizures, and patients with temporal lobe epilepsy show increased brain temperature, likely due to chronic brain inflammation. Cooling the brain has been shown to help reduce seizures and neuronal damage, but the process can be risky and is not feasible for long term therapy. This project explores a safer alternative: using a small molecule called an ASO (antisense oligonucleotide).
ASOs can attach to specific RNA sequences inside cells and control gene expression. The ASO developed by this team activates a “cold shock” protein named RBM3 that protects brain cells—without needing to cool the body. Initial data show that ASO treatment can improve recovery after status epilepticus. If successful, this new approach could offer a breakthrough therapy to prevent epilepsy, especially in patients recovering from brain injuries or severe seizures.
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