Prevention of Acquired Epilepsies Awards, Funded by the Brighter Future Award
Thomas Sutula, MD, PhD / University of Wisconsin, Madison
This project is addressing this significant need by determining if administration of 2DG, a novel sugar analogue that blocks sugar metabolism, at the time of TBI reduces or prevents later development of post-traumatic epilepsy.
Prevention of Acquired Epilepsies Awards
Xiaoming Jin, PhD / Indiana University School of Medicine
In this project, we will use an animal model to determine brain injury-induced changes in HMGB1 and its receptors and their contribution to the development of epilepsy.
Prevention of Acquired Epilepsies Awards
Daniela Kaufer, PhD / The Regents of the University of California, Berkeley
Our ultimate goal is to develop a clinical protocol that will identify patients with BBB dysfunction, prior to the onset of epilepsy, and accordingly individualize a preventive therapeutic intervention.
SUDEP, Funded by the Christopher Donalty and Kyle Coggins Award
Franck Kalume, PhD / Seattle Children’s Research Institute
We will conduct experiments to Identify and compare the cardiac, respiratory, and post-seizure brain activity changes that predict SUDEP susceptibility in DS and FCD mice.
SUDEP, Funded by the Henry Lapham Memorial Award
Lisa Bateman, MD / Columbia University Medical Center
It is hoped that the information learned from this study will lead to an increased understanding of individual SUDEP risk prediction and help to guide patients and their doctors in making clinical care decisions related to epilepsy surgery.
Challenge Award, Funded by the CJM Foundation
Braxton Norwood, PhD / Phillips Universitaet Marburg, Germany
We recently discovered that mice with particular TLR dysregulation exhibit spontaneous seizures in adulthood, despite having normal brain structure. We hypothesize that this immune system dysfunction causes epilepsy.
Challenge Award, Funded by the Madison Friends of CURE Award
Anne Schaefer, MD, PhD / Icahn School of Medicine at Mt. Sinai
Our aim is to use miR-128 or its antagonists to suppress pathological neuron excitation causing fatal epilepsy in mice, and to extend our findings to further advance human epilepsy treatment.
Taking Flight Award
Catherine Christian, PhD / University of Illinois at Urbana-Champaign
The proposed studies will focus on using newly developed methods to selectively stimulate astrocytes in the nRT using light, and assess the effects of this stimulation on both synaptic inhibition and absence seizures.
Challenge Award
David Henshall, PhD / Royal College of Surgeons in Ireland
This project will test models of autoantibody transfer to determine if these LGI1 antibodies are sufficient to cause seizures and interfere with brain functions such as memory.
